Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin

Loss of protein homeostasis is a hallmark of the aging process. We and others have previously shown that maintenance of proteostasis is a shared characteristic of slowed-aging models. Rapamycin (Rap) exerts sex-specific effects on murine lifespan, but the combination of Rap with the anti-hyperglycem...

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Pubblicato in:GeroScience
Autori principali: Wolff, Christopher A., Lawrence, Marcus M., Porter, Hunter, Zhang, Qian, Reid, Justin J., Laurin, Jaime L., Musci, Robert V., Linden, Melissa A., Peelor, Frederick F., Wren, Jonathan D., Creery, Joseph S., Cutler, Kyle J., Carson, Richard H., Price, John C., Hamilton, Karyn L., Miller, Benjamin F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110668/
https://ncbi.nlm.nih.gov/pubmed/32761290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00243-8
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