Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin

Loss of protein homeostasis is a hallmark of the aging process. We and others have previously shown that maintenance of proteostasis is a shared characteristic of slowed-aging models. Rapamycin (Rap) exerts sex-specific effects on murine lifespan, but the combination of Rap with the anti-hyperglycem...

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Vydáno v:GeroScience
Hlavní autoři: Wolff, Christopher A., Lawrence, Marcus M., Porter, Hunter, Zhang, Qian, Reid, Justin J., Laurin, Jaime L., Musci, Robert V., Linden, Melissa A., Peelor, Frederick F., Wren, Jonathan D., Creery, Joseph S., Cutler, Kyle J., Carson, Richard H., Price, John C., Hamilton, Karyn L., Miller, Benjamin F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2020
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110668/
https://ncbi.nlm.nih.gov/pubmed/32761290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00243-8
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