Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin

Loss of protein homeostasis is a hallmark of the aging process. We and others have previously shown that maintenance of proteostasis is a shared characteristic of slowed-aging models. Rapamycin (Rap) exerts sex-specific effects on murine lifespan, but the combination of Rap with the anti-hyperglycem...

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Foilsithe in:GeroScience
Main Authors: Wolff, Christopher A., Lawrence, Marcus M., Porter, Hunter, Zhang, Qian, Reid, Justin J., Laurin, Jaime L., Musci, Robert V., Linden, Melissa A., Peelor, Frederick F., Wren, Jonathan D., Creery, Joseph S., Cutler, Kyle J., Carson, Richard H., Price, John C., Hamilton, Karyn L., Miller, Benjamin F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer International Publishing 2020
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110668/
https://ncbi.nlm.nih.gov/pubmed/32761290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-020-00243-8
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