Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer’s disease

Synaptic disturbances in excitatory to inhibitory (E/I) balance in forebrain circuits are thought to contribute to the progression of Alzheimer’s disease (AD) and dementia, although direct evidence for such imbalance in humans is lacking. We assessed anatomical and electrophysiological synaptic E/I...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Lauterborn, Julie C., Scaduto, Pietro, Cox, Conor D., Schulmann, Anton, Lynch, Gary, Gall, Christine M., Keene, C. Dirk, Limon, Agenor
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110554/
https://ncbi.nlm.nih.gov/pubmed/33972518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22742-8
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