LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

Adult neural stem cells (NSCs) must tightly regulate quiescence and proliferation. Single-cell analysis has suggested a continuum of cell states as NSCs exit quiescence. Here we capture and characterize in vitro primed quiescent NSCs and identify LRIG1 as an important regulator. We show that BMP-4 s...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Marqués-Torrejón, María Ángeles, Williams, Charles A. C., Southgate, Benjamin, Alfazema, Neza, Clements, Melanie P., Garcia-Diaz, Claudia, Blin, Carla, Arranz-Emparan, Nerea, Fraser, Jane, Gammoh, Noor, Parrinello, Simona, Pollard, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110534/
https://ncbi.nlm.nih.gov/pubmed/33972529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22813-w
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