Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

Clonal hematopoiesis, a condition in which individual hematopoietic stem cell clones generate a disproportionate fraction of blood leukocytes, correlates with higher risk for cardiovascular disease. The mechanisms behind this association are incompletely understood. Here we show that hematopoietic s...

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Pubblicato in:Cell
Autori principali: Heyde, Alexander, Rohde, David, McAlpine, Cameron S., Zhang, Shuang, Hoyer, Friedrich F., Gerold, Jeffrey M., Cheek, David, Iwamoto, Yoshiko, Schloss, Maximilian J., Vandoorne, Katrien, Iborra-Egea, Oriol, Muñoz-Guijosa, Christian, Bayes-Genis, Antoni, Reiter, Johannes G., Craig, Morgan, Swirski, Filip K., Nahrendorf, Matthias, Nowak, Martin A., Naxerova, Kamila
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8109274/
https://ncbi.nlm.nih.gov/pubmed/33636128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.01.049
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