Deletion of the endogenous TrkB.T1 receptor isoform restores the number of hippocampal CA1 parvalbumin-positive neurons and rescues long-term potentiation in pre-symptomatic mSOD1(G93A) ALS mice

Amyotrophic lateral sclerosis (ALS) causes rapidly progressive paralysis and death within 5 years from diagnosis due to degeneration of the motor circuits. However, a significant population of ALS patients also shows cognitive impairments and progressive hippocampal pathology. Likewise, the mutant S...

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Publicado en:Mol Cell Neurosci
Autores principales: Quarta, Eros, Fulgenzi, Gianluca, Bravi, Riccardo, Cohen, Erez James, Yanpallewar, Sudhirkumar, Tessarollo, Lino, Minciacchi, Diego
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8108068/
https://ncbi.nlm.nih.gov/pubmed/29580900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2018.03.010
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