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ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice

PURPOSE: In POAG, elevated IOP remains the major risk factor in irreversible vision loss. Increased TGFβ2 expression in POAG aqueous humor and in the trabecular meshwork (TM) amplifies extracellular matrix (ECM) deposition and reduces ECM turnover in the TM, leading to a decreased aqueous humor (AH)...

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Publicat a:Invest Ophthalmol Vis Sci
Autors principals: Mody, Avani A., Millar, J. Cameron, Clark, Abbot F.
Format: Artigo
Idioma:Inglês
Publicat: The Association for Research in Vision and Ophthalmology 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8107646/
https://ncbi.nlm.nih.gov/pubmed/33938911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.6.3
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