Novel nanopolymer RNA therapeutics normalize human diabetic corneal wound healing and epithelial stem cells

Human diabetic corneas develop delayed wound healing, epithelial stem cell dysfunction, recurrent erosions, and keratitis. Adenoviral gene therapy modulating c-Met, cathepsin F and MMP-10 normalized wound healing and epithelial stem cells in organ-cultured diabetic corneas but showed toxicity in ste...

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Detalhes bibliográficos
Publicado no:Nanomedicine
Main Authors: Kramerov, Andrei A., Shah, Ruchi, Ding, Hui, Holler, Eggehard, Turjman, Sue, Rabinowitz, Yaron S., Ghiam, Sean, Maguen, Ezra, Svendsen, Clive N., Saghizadeh, Mehrnoosh, Ljubimova, Julia Y., Ljubimov, Alexander V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8107190/
https://ncbi.nlm.nih.gov/pubmed/33181273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2020.102332
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