Novel nanopolymer RNA therapeutics normalize human diabetic corneal wound healing and epithelial stem cells

Human diabetic corneas develop delayed wound healing, epithelial stem cell dysfunction, recurrent erosions, and keratitis. Adenoviral gene therapy modulating c-Met, cathepsin F and MMP-10 normalized wound healing and epithelial stem cells in organ-cultured diabetic corneas but showed toxicity in ste...

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Publicado en:Nanomedicine
Main Authors: Kramerov, Andrei A., Shah, Ruchi, Ding, Hui, Holler, Eggehard, Turjman, Sue, Rabinowitz, Yaron S., Ghiam, Sean, Maguen, Ezra, Svendsen, Clive N., Saghizadeh, Mehrnoosh, Ljubimova, Julia Y., Ljubimov, Alexander V.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8107190/
https://ncbi.nlm.nih.gov/pubmed/33181273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2020.102332
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