Activity of tarloxotinib‐E in cells with EGFR exon‐20 insertion mutations and mechanisms of acquired resistance

BACKGROUND: Approximately 10% of non‐small cell lung cancers (NSCLCs) that harbor epidermal growth factor receptor (EGFR) gene mutations have in‐frame insertions in exon 20 of the EGFR gene. These tumors do not usually respond to currently available EGFR‐tyrosine kinase inhibitors (TKIs). Tarloxotin...

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Bibliografiske detaljer
Udgivet i:Thorac Cancer
Main Authors: Nishino, Masaya, Suda, Kenichi, Koga, Takamasa, Ohara, Shuta, Fujino, Toshio, Soh, Junichi, Tirunagaru, Vijaya, Vellanki, Avanish, Doebele, Robert C., Mitsudomi, Tetsuya
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons Australia, Ltd 2021
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8107039/
https://ncbi.nlm.nih.gov/pubmed/33710795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1759-7714.13931
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