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An insight into the inhibitory mechanism of phytochemicals and FDA-approved drugs on the ACE2–Spike complex of SARS-CoV-2 using computational methods

The S-glycoprotein (Spike) of the SARS-CoV-2 forms a complex with the human transmembrane protein angiotensin-converting enzyme 2 (ACE2) during infection. It forms the first line of contact with the human cell. The FDA-approved drugs and phytochemicals from Indian medicinal plants were explored. Mol...

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Publicado en:Chem Zvesti
Autores principales: Jani, Vinod, Koulgi, Shruti, Uppuladinne, V. N. Mallikarjunachari, Sonavane, Uddhavesh, Joshi, Rajendra
Formato: Artigo
Lenguaje:Inglês
Publicado: Versita 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106519/
https://ncbi.nlm.nih.gov/pubmed/33994655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11696-021-01680-1
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