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Using historical data to facilitate clinical prevention trials in Alzheimer disease? An analysis of longitudinal MCI (mild cognitive impairment) data sets

BACKGROUND: The Placebo Group Simulation Approach (PGSA) aims at partially replacing randomized placebo-controlled trials (RPCTs), making use of data from historical control groups in order to decrease the needed number of study participants exposed to lengthy placebo treatment. PGSA algorithms to c...

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Publicat a:Alzheimers Res Ther
Autors principals: Berres, Manfred, Monsch, Andreas U., Spiegel, René
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106156/
https://ncbi.nlm.nih.gov/pubmed/33962665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-021-00832-5
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