Apelin receptor upregulation in spontaneously hypertensive rat contributes to the enhanced vascular smooth muscle cell proliferation by activating autophagy

BACKGROUND: Proliferation of vascular smooth muscle cells (VSMCs) plays a vital role in the progression of vascular remodeling and hypertension. Apelin-13 promotes VSMC proliferation of normal rats. This study was designed to investigate the roles of apelin receptor (APJ) and apelin-13 in VSMC proli...

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Bibliographic Details
Published in:Ann Transl Med
Main Authors: Xu, Tao, Jia, Jian, Xu, Na, Ye, Chao, Zheng, Fen, Yuan, Yan, Zhu, Guo-Qing, Zhan, Yi-Yang
Format: Artigo
Language:Inglês
Published: AME Publishing Company 2021
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106044/
https://ncbi.nlm.nih.gov/pubmed/33987325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm-20-6891
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