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Image-derived modeling of nucleus strain amplification associated with chromatin heterogeneity

Beyond the critical role of cell nuclei in gene expression and DNA replication, they also have a significant influence on cell mechanosensation and migration. Nuclear stiffness can impact force transmission and, furthermore, act as a physical barrier to translocation across tight spaces. As such, it...

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Vydáno v:Biophys J
Hlavní autoři: Reynolds, Noel, McEvoy, Eoin, Ghosh, Soham, Panadero Pérez, Juan Alberto, Neu, Corey P., McGarry, Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8105730/
https://ncbi.nlm.nih.gov/pubmed/33675762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2021.01.040
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