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Cholesterol stabilizes recombinant exocytic fusion pores by altering membrane bending rigidity

SNARE-mediated membrane fusion proceeds via the formation of a fusion pore. This intermediate structure is highly dynamic and can flicker between open and closed states. In cells, cholesterol has been reported to affect SNARE-mediated exocytosis and fusion pore dynamics. Here, we address the questio...

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Bibliographische Detailangaben
Veröffentlicht in:Biophys J
Hauptverfasser: Wu, Lanxi, Courtney, Kevin C., Chapman, Edwin R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8105710/
https://ncbi.nlm.nih.gov/pubmed/33582136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2021.02.005
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