Gamabufotalin Inhibits Osteoclastgenesis and Counteracts Estrogen-Deficient Bone Loss in Mice by Suppressing RANKL-Induced NF-κB and ERK/MAPK Pathways

Osteolytic bone disease is a condition of imbalanced bone homeostasis, characterized mainly by excessive bone-resorptive activity, which could predispose these populations, such as the old and postmenopausal women, to developing high risk of skeletal fragility and fracture. The nature of bone homeos...

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Vydáno v:Front Pharmacol
Hlavní autoři: Sun, Kaiqiang, Zhu, Jian, Deng, Yi, Xu, Ximing, Kong, Fanqi, Sun, Xiaofei, Huan, Le, Ren, Changzhen, Sun, Jingchuan, Shi, Jiangang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8104077/
https://ncbi.nlm.nih.gov/pubmed/33967763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.629968
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