Effect of Subcutaneous Anti-CD20 Antibody-Mediated B Cell Depletion on Susceptibility to Pneumocystis Infection in Mice

Prior work has shown that parenterally administered anti-CD20 (5D2) inhibits CD4(+) T cell priming in response to challenge with Pneumocystis murina and predisposes to pneumonia. In this study, we investigated the effect of subcutaneous anti-CD20 antibody and Pneumocystis infection. In mice with pri...

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Bibliographic Details
Published in:mSphere
Main Authors: Dai, Guixiang, Noell, Kristin, Weckbecker, Gisbert, Kolls, Jay K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103991/
https://ncbi.nlm.nih.gov/pubmed/33952667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.01144-20
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