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ARG-513 AND LEU-531 ARE KEY RESIDUES GOVERNING TIME-DEPENDENT INHIBITION OF CYCLOOXYGENASE-2 BY ASPIRIN AND CELEBREX
Aspirin and Celebrex are well-known time-dependent inhibitors of the Cyclooxygenases (COX). Molecular dynamics simulations suggest that Arg-513 and Leu-531 contribute to the structural mechanisms of COX inhibition. We used mutagenesis and functional analyses to characterize how substitutions at thes...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8103790/ https://ncbi.nlm.nih.gov/pubmed/31469551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00659 |
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