Emodin Alleviates Severe Acute Pancreatitis-Associated Acute Lung Injury by Inhibiting the Cold-Inducible RNA-Binding Protein (CIRP)-Mediated Activation of the NLRP3/IL-1β/CXCL1 Signaling

Objective: Severe acute pancreatitis (SAP) can lead to acute lung injury (ALI). This study investigated the therapeutic effect of emodin and its molecular mechanisms in a rat model of SAP-ALI. Methods: Forty male Sprague-Dawley rats were randomly divided into the groups: Control (CON), SAP (SAP), em...

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Bibliografische gegevens
Gepubliceerd in:Front Pharmacol
Hoofdauteurs: Xu, Qiushi, Wang, Mengfei, Guo, Haoya, Liu, Huanhuan, Zhang, Guixin, Xu, Caiming, Chen, Hailong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021
Onderwerpen:
Pharmacology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103163/
https://ncbi.nlm.nih.gov/pubmed/33967799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.655372
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