Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers

Treatment of cancers in the lung remains a critical challenge in the clinic for which gene therapy could offer valuable options. We describe an effective approach through systemic injection of engineered polymer/DNA nanoparticles that mediate tumor-specific expression of a therapeutic gene, under th...

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Publicat a:Sci Rep
Autors principals: Ahn, Hye-Hyun, Carrington, Christine, Hu, Yizong, Liu, Heng-wen, Ng, Christy, Nam, Hwanhee, Park, Andrew, Stace, Catherine, West, Will, Mao, Hai-Quan, Pomper, Martin G., Ullman, Christopher G., Minn, Il
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102550/
https://ncbi.nlm.nih.gov/pubmed/33958660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89124-4
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