Structural and mechanistic insights into the bifunctional HISN2 enzyme catalyzing the second and third steps of histidine biosynthesis in plants

The second and third steps of the histidine biosynthetic pathway (HBP) in plants are catalyzed by a bifunctional enzyme–HISN2. The enzyme consists of two distinct domains, active respectively as a phosphoribosyl-AMP cyclohydrolase (PRA-CH) and phosphoribosyl-ATP pyrophosphatase (PRA-PH). The domains...

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Vydáno v:Sci Rep
Hlavní autoři: Witek, Wojciech, Sliwiak, Joanna, Ruszkowski, Milosz
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102479/
https://ncbi.nlm.nih.gov/pubmed/33958623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88920-2
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