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The effect of 220 kHz insonation scheme on rt-PA thrombolytic efficacy in vitro

Ultrasound-enhanced recombinant tissue plasminogen activator (rt-PA) mediated thrombolysis is under development as an adjuvant to ischemic stroke therapy. The goal of this study was to design a pulsed ultrasound (US) scheme that reduced intracranial constructive interference and tissue heating, and...

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Publicat a:Phys Med Biol
Autors principals: Kleven, Robert T., Karani, Kunal B., Salido, Nuria G., Shekhar, Himanshu, Haworth, Kevin J., Mast, T. Douglas, Tadesse, Dawit G., Holland, Christy K.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102059/
https://ncbi.nlm.nih.gov/pubmed/31189149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1088/1361-6560/ab293b
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