PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca(2+) efflux

BACKGROUND: Sepsis is a systemic inflammatory response to a local severe infection that may lead to multiple organ failure and death. Previous studies have shown that 40–50% of patients with sepsis have diverse myocardial injuries and 70 to 90% mortality rates compared to 20% mortality in patients w...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Zhou, Qin, Xie, Min, Zhu, Jing, Yi, Qin, Tan, Bin, Li, Yasha, Ye, Liang, Zhang, Xinyuan, Zhang, Ying, Tian, Jie, Xu, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101124/
https://ncbi.nlm.nih.gov/pubmed/33957982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02325-6
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