m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner

Nucleic acid sensing through pattern recognition receptors is critical for immune recognition of microbial infections. Microbial DNA is frequently methylated at the N(6) position of adenines (m6A), a modification that is rare in mammalian host DNA. We show here how that m6A methylation of 5′-GATC-3′...

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Udgivet i:Open Biol
Main Authors: Balzarolo, Melania, Engels, Sander, de Jong, Anja J., Franke, Katka, van den Berg, Timo K., Gulen, Muhammet F., Ablasser, Andrea, Janssen, Edith M., van Steensel, Bas, Wolkers, Monika C.
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101014/
https://ncbi.nlm.nih.gov/pubmed/33715389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.210030
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