Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury

BACKGROUND & AIMS: Mitochondria are the major organelles for the formation of reactive oxygen species (ROS) in the cell, and mitochondrial dysfunction has been described as a key factor in the pathogenesis of cholestatic liver disease. The methylation-controlled J-protein (MCJ) is a mitochondria...

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Published in:JHEP Rep
Main Authors: Iruzubieta, Paula, Goikoetxea-Usandizaga, Naroa, Barbier-Torres, Lucía, Serrano-Maciá, Marina, Fernández-Ramos, David, Fernández-Tussy, Pablo, Gutiérrez-de-Juan, Virginia, Lachiondo-Ortega, Sofia, Simon, Jorge, Bravo, Miren, Lopitz-Otsoa, Fernando, Robles, Mercedes, Ferre-Aracil, Carlos, Varela-Rey, Marta, Elguezabal, Natalia, Calleja, José Luis, Lu, Shelly C., Milkiewicz, Malgorzata, Milkiewicz, Piotr, Anguita, Juan, Monte, María J., Marin, José J.G., López-Hoyos, Marcos, Delgado, Teresa C., Rincón, Mercedes, Crespo, Javier, Martínez-Chantar, María Luz
Format: Artigo
Language:Inglês
Published: Elsevier 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099785/
https://ncbi.nlm.nih.gov/pubmed/33997750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhepr.2021.100276
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