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Evaluation by simulation of clinical trial designs for evaluation of treatment during a viral haemorrhagic fever outbreak

BACKGROUND: Viral haemorrhagic fevers are characterized by irregular outbreaks with high mortality rate. Difficulties arise when implementing therapeutic trials in this context. The outbreak duration is hard to predict and can be short compared to delays of trial launch and number of subject needed...

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Detalhes bibliográficos
Publicado no:BMC Med Res Methodol
Main Authors: Manchon, Pauline, Belhadi, Drifa, Mentré, France, Laouénan, Cédric
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099711/
https://ncbi.nlm.nih.gov/pubmed/33952195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-021-01287-w
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