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Exploring Ubiquinone Biosynthesis Inhibition as a Strategy for Improving Atovaquone Efficacy in Malaria
Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH(2)) for its union to the mitochondrial bc(1) complex, preventing the ubiquinone-8 and ubiquinone-9 (UQ-8 and UQ-9) redox recycling, which is a necessary step in pyrimidine biosynthesis. This study focused on UQ biosynthesi...
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| Publicado no: | Antimicrob Agents Chemother |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8097429/ https://ncbi.nlm.nih.gov/pubmed/33495230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01516-20 |
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