Using a bistable animal opsin for switchable and scalable optogenetic inhibition of neurons

There is no consensus on the best inhibitory optogenetic tool. Since Gi/o signalling is a native mechanism of neuronal inhibition, we asked whether Lamprey Parapinopsin (“Lamplight”), a Gi/o‐coupled bistable animal opsin, could be used for optogenetic silencing. We show that short (405 nm) and long...

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Pubblicato in:EMBO Rep
Autori principali: Rodgers, Jessica, Bano‐Otalora, Beatriz, Belle, Mino D C, Paul, Sarika, Hughes, Rebecca, Wright, Phillip, McDowell, Richard, Milosavljevic, Nina, Orlowska‐Feuer, Patrycja, Martial, Franck P, Wynne, Jonathan, Ballister, Edward R, Storchi, Riccardo, Allen, Annette E, Brown, Timothy, Lucas, Robert J
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
Soggetti:
Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097317/
https://ncbi.nlm.nih.gov/pubmed/33655694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202051866
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