A Chemo-Genomic Approach Identifies Diverse Epigenetic Therapeutic Vulnerabilities in MYCN-Amplified Neuroblastoma

Although a rare disease, neuroblastoma accounts for the highest proportion of childhood cancer deaths. There is a lack of recurrent somatic mutations in neuroblastoma embryonal tumours, suggesting a possible role for epigenetic alterations in driving this cancer. While an increasing number of report...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Krstic, Aleksandar, Konietzny, Anja, Halasz, Melinda, Cain, Peter, Oppermann, Udo, Kolch, Walter, Duffy, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097097/
https://ncbi.nlm.nih.gov/pubmed/33968920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.612518
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