Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

Colistin is an antibiotic of last resort, but has poor efficacy and resistance is a growing problem. Whilst it is well established that colistin disrupts the bacterial outer membrane (OM) by selectively targeting lipopolysaccharide (LPS), it was unclear how this led to bacterial killing. We discover...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sabnis, Akshay, Hagart, Katheryn LH, Klöckner, Anna, Becce, Michele, Evans, Lindsay E, Furniss, R Christopher D, Mavridou, Despoina AI, Murphy, Ronan, Stevens, Molly M, Davies, Jane C, Larrouy-Maumus, Gérald J, Clarke, Thomas B, Edwards, Andrew M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Microbiology and Infectious Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096433/
https://ncbi.nlm.nih.gov/pubmed/33821795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.65836
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