DNA Hypermethylation Induced by L-Methionine Leads to Oligodendroglial and Myelin Deficits and Schizophrenia-Like Behaviors in Adolescent Mice

Increasing evidence has demonstrated that in addition to dysfunction of neuronal circuitry, oligodendroglial dysfunction and/or disruption of white matter integrity are found in the brains of patients with schizophrenia. DNA methylation, a well-established risk factor for schizophrenia, has been dem...

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Publicado en:Front Neurosci
Autores principales: Chen, Xianjun, Huang, Nan-Xin, Cheng, Yong-Jie, Cai, Qi-Yan, Tian, Yan-Ping, Chen, Xing-Shu, Xiao, Lan
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095669/
https://ncbi.nlm.nih.gov/pubmed/33958986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.659853
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