Ileal Transcriptomic Analysis in Paediatric Crohn’s Disease Reveals IL17- and NOD-signalling Expression Signatures in Treatment-naïve Patients and Identifies Epithelial Cells Driving Differentially Expressed Genes

BACKGROUND AND AIMS: Crohn’s disease [CD] arises through host-environment interaction. Abnormal gene expression results from disturbed pathway activation or response to bacteria. We aimed to determine activated pathways and driving cell types in paediatric CD. METHODS: We employed contemporary targe...

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Bibliografski detalji
Izdano u:J Crohns Colitis
Glavni autori: Ashton, James J, Boukas, Konstantinos, Davies, James, Stafford, Imogen S, Vallejo, Andres F, Haggarty, Rachel, Coelho, Tracy A F, Batra, Akshay, Afzal, Nadeem A, Vadgama, Bhumita, Williams, Anthony P, Beattie, R Mark, Polak, Marta E, Ennis, Sarah
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095388/
https://ncbi.nlm.nih.gov/pubmed/33232439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjaa236
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