Roux-en-Y gastric bypass contributes to weight loss-independent improvement in hypothalamic inflammation and leptin sensitivity through gut-microglia-neuron-crosstalk

OBJECTIVE: Hypothalamic inflammation and endoplasmic reticulum (ER) stress are extensively linked to leptin resistance and overnutrition-related diseases. Surgical intervention remains the most efficient long-term weight-loss strategy for morbid obesity, but mechanisms underlying sustained feeding s...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Metab
Main Authors: Chen, Jiesi, Haase, Nadine, Haange, Sven-Bastiaan, Sucher, Robert, Münzker, Julia, Jäger, Elisabeth, Schischke, Kristin, Seyfried, Florian, von Bergen, Martin, Hankir, Mohammed K., Krügel, Ute, Fenske, Wiebke K.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2021
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095174/
https://ncbi.nlm.nih.gov/pubmed/33741533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101214
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