Activated IL-6 signaling contributes to the pathogenesis of, and is a novel therapeutic target for, CALR-mutated MPNs

Calreticulin (CALR), an endoplasmic reticulum–associated chaperone, is frequently mutated in myeloproliferative neoplasms (MPNs). Mutated CALR promotes downstream JAK2/STAT5 signaling through interaction with, and activation of, the thrombopoietin receptor (MPL). Here, we provide evidence of a novel...

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Bibliographische Detailangaben
Veröffentlicht in:Blood Adv
Hauptverfasser: Balliu, Manjola, Calabresi, Laura, Bartalucci, Niccolò, Romagnoli, Simone, Maggi, Laura, Manfredini, Rossella, Lulli, Matteo, Guglielmelli, Paola, Vannucchi, Alessandro Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2021
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095134/
https://ncbi.nlm.nih.gov/pubmed/33890979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003291
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