Absolute lymphocyte count proliferation kinetics after CAR T-cell infusion impact response and relapse

CD19-directed chimeric antigen receptor (CAR) T cells show characteristic proliferation kinetics after infusion that correlate with response. Clearance of circulating disease, B-cell aplasia (BCA), and cytokine release syndrome (CRS) are used to observe CAR T-cell function, given the lack of commerc...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Faude, Sophia, Wei, Jane, Muralidharan, Kavitha, Xu, Xiaoming, Wertheim, Gerald, Paessler, Michele, Bhoj, Vijay G., Grupp, Stephan A., Maude, Shannon L., Rheingold, Susan R., Pillai, Vinodh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Immunobiology and Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095130/
https://ncbi.nlm.nih.gov/pubmed/33881465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020004038
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