RASSF1A, BLU, NORE1A, PTEN and MGMT Expression and Promoter Methylation in Gliomas and Glioma Cell Lines and Evidence of Deregulated Expression of de novo DNMTs

Methylation of CpG islands in gene promoters can lead to gene silencing. Together with deletion or mutation, it may cause a loss of function of tumor suppressor genes. RASSF1A (3p21.3), NORE1A (1q32.1) and BLU (3p21.3) have been shown to be downregulated by methylation in cancer, and PTEN (10q23.3)...

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Bibliographic Details
Published in:Brain Pathol
Main Authors: Lorente, Aiala, Mueller, Wolf, Urdangarín, Edurne, Lázcoz, Paula, Lass, Ulrike, Von Deimling, Andreas, Castresana, Javier S.
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2008
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094756/
https://ncbi.nlm.nih.gov/pubmed/18616639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2008.00185.x
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