Recent advances in the understanding of the molecular pathogenesis and targeted therapy options in Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is the most common histiocytic disorder caused by the clonal expansion of myeloid precursors that differentiate into CD1a+/CD207+ cells in the lesion. Advances in genomic sequencing techniques have improved our understanding of the pathophysiology of LCH. Activati...

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Bibliographic Details
Published in:Blood Res
Main Authors: Suh, Jin Kyung, Kang, Sunghan, Kim, Hyery, Im, Ho Joon, Koh, Kyung-Nam
Format: Artigo
Language:Inglês
Published: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2021
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093998/
https://ncbi.nlm.nih.gov/pubmed/33935037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5045/br.2021.2021013
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