Selective HDAC8 Inhibition Attenuates Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis via p38 MAPK Pathway

Histone deacetylase (HDAC) expression and enzymatic activity are dysregulated in cardiovascular diseases. Among Class I HDACs, HDAC2 has been reported to play a key role in cardiac hypertrophy; however, the exact function of HDAC8 remains unknown. Here we investigated the role of HDAC8 in cardiac hy...

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Vydáno v:Front Pharmacol
Hlavní autoři: Zhao, Tingwei, Kee, Hae Jin, Bai, Liyan, Kim, Moon-Ki, Kee, Seung-Jung, Jeong, Myung Ho
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093872/
https://ncbi.nlm.nih.gov/pubmed/33959033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.677757
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