Reck-Notch1 Signaling Mediates miR-221/222 Regulation of Lung Cancer Stem Cells in NSCLC

Cancer stem cells (CSCs) contribute to the cancer initiation, metastasis and drug resistance in non-small cell lung cancer (NSCLC). Herein, we identified a miR-221/222 cluster as a novel regulator of CSCs in NSCLC. Targeted overexpression or knockdown of miR-221/222 in NSCLC cells revealed the essen...

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Pubblicato in:Front Cell Dev Biol
Autori principali: Guo, Yuefan, Wang, Guangxue, Wang, Zhongrui, Ding, Xin, Qian, Lu, Li, Ya, Ren, Zhen, Liu, Pengfei, Ma, Wenjing, Li, Danni, Li, Yuan, Zhao, Qian, Lü, Jinhui, Li, Qinchuan, Wang, Qinhong, Yu, Zuoren
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Cell and Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093830/
https://ncbi.nlm.nih.gov/pubmed/33959615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.663279
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