Rapamycin Promotes ROS-Mediated Cell Death via Functional Inhibition of xCT Expression in Melanoma Under γ-Irradiation

Although many cancer patients are administered radiotherapy for their treatment, the interaction between tumor cells and macrophages in the tumor microenvironment attenuates the curative effects of radiotherapy. The enhanced activation of mTOR signaling in the tumors promotes tumor radioresistance....

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Veröffentlicht in:Front Oncol
Hauptverfasser: Woo, Yunseo, Lee, Hyo-Ji, Kim, Jeongyeon, Kang, Seung Goo, Moon, Sungjin, Han, Jeong A., Jung, Young Mee, Jung, Yu-Jin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093631/
https://ncbi.nlm.nih.gov/pubmed/33959512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.665420
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