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Shark Antibody Variable Domains Rigidify Upon Affinity Maturation—Understanding the Potential of Shark Immunoglobulins as Therapeutics

Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that have antibodies as part of their adaptive immune system. As part of their humoral adaptive immune response, they produce an immunoglobulin, the so-called immunoglobulin new antigen receptor (IgNAR), a heavy-cha...

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Publicat a:Front Mol Biosci
Autors principals: Fernández-Quintero, Monica L., Seidler, Clarissa A., Quoika, Patrick K., Liedl, Klaus R.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093575/
https://ncbi.nlm.nih.gov/pubmed/33959632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.639166
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