Conformational distortion in a fibril-forming oligomer arrests alpha-Synuclein fibrillation and minimizes its toxic effects

The fibrillation pathway of alpha-Synuclein, the causative protein of Parkinson’s disease, encompasses transient, heterogeneous oligomeric forms whose structural understanding and link to toxicity are not yet understood. We report that the addition of the physiologically-available small molecule hem...

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Veröffentlicht in:Commun Biol
Hauptverfasser: Chakraborty, Ritobrita, Dey, Sandip, Sil, Pallabi, Paul, Simanta Sarani, Bhattacharyya, Dipita, Bhunia, Anirban, Sengupta, Jayati, Chattopadhyay, Krishnananda
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093279/
https://ncbi.nlm.nih.gov/pubmed/33941845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02026-z
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