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Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment

Chimeric antigen receptor (CAR)-T cell therapy has achieved successful outcomes against hematological malignancies and provided a new impetus for treating solid tumors. However, the efficacy of CAR-T cells for solid tumors remains unsatisfactory. The tumor microenvironment has an important role in i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cell Mol Immunol
Hauptverfasser: Liu, Guangna, Rui, Wei, Zhao, Xueqiang, Lin, Xin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093220/
https://ncbi.nlm.nih.gov/pubmed/33785843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-021-00655-2
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