Enhanced Ca(2+) signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model (Cacna1h(M1560V/+))

Gain-of-function mutations in the CACNA1H gene (encoding the T-type calcium channel Ca(V)3.2) cause autosomal-dominant familial hyperaldosteronism type IV (FH-IV) and early-onset hypertension in humans. We used CRISPR/Cas9 to generate Cacna1h(M1560V/+) knockin mice as a model of the most common FH-I...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Seidel, Eric, Schewe, Julia, Zhang, Junhui, Dinh, Hoang An, Forslund, Sofia K., Markó, Lajos, Hellmig, Nicole, Peters, Jörg, Muller, Dominik N., Lifton, Richard P., Nottoli, Timothy, Stölting, Gabriel, Scholl, Ute I.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2021
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092574/
https://ncbi.nlm.nih.gov/pubmed/33879608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014876118
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