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Effects of Regulatory Network Organization and Environment on PmrD Connector Activity and Polymyxin Resistance in Klebsiella pneumoniae and Escherichia coli

Polymyxins are a class of cyclic peptides with antimicrobial activity against Gram-negative bacteria. In Enterobacteriaceae, the PhoQ/PhoP and PmrB/PmrA two-component systems regulate many genes that confer resistance to both polymyxins and host antimicrobial peptides. The activities of these two-co...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Chen, Annie I., Albicoro, Francisco Javier, Zhu, Jun, Goulian, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092550/
https://ncbi.nlm.nih.gov/pubmed/33361295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00889-20
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