In Vitro Selection Implicates ROP1 as a Resistance Gene for an Experimental Therapeutic Benzoquinone Acyl Hydrazone in Toxoplasma gondii

Toxoplasma gondii is a globally distributed apicomplexan parasite and the causative agent of toxoplasmosis in humans. While pharmaceuticals exist to combat acute infection, they can produce serious adverse reactions, demonstrating a need for enhanced therapies. KG8 is a benzoquinone acyl hydrazone c...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Martens, Matthew C., Won, Madalyn M., Won, Harim I., Schulze, Thomas T., Judge, Abigail K., Neville, Andrew J., Vennerstrom, Jonathan L., Davis, Paul H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2021
Matèries:
Mechanisms of Resistance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092512/
https://ncbi.nlm.nih.gov/pubmed/33361291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01040-20
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