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Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos
Polycomb repressive complexes 1 and 2 (PRC1/2) maintain transcriptional silencing of developmental genes largely by catalyzing mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub1) and trimethylation of histone H3 at lysine 27 (H3K27me3), respectively. How Polycomb domains are reprogrammed d...
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| Published in: | Nat Genet |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8092361/ https://ncbi.nlm.nih.gov/pubmed/33821005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00821-2 |
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