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Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos

Polycomb repressive complexes 1 and 2 (PRC1/2) maintain transcriptional silencing of developmental genes largely by catalyzing mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub1) and trimethylation of histone H3 at lysine 27 (H3K27me3), respectively. How Polycomb domains are reprogrammed d...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Chen, Zhiyuan, Djekidel, Mohamed Nadhir, Zhang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092361/
https://ncbi.nlm.nih.gov/pubmed/33821005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00821-2
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