Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex

Complement, contact activation, coagulation, and fibrinolysis are serum protein cascades that need strict regulation to maintain human health. Serum glycoprotein, a C1 inhibitor (C1-INH), is a key regulator (inhibitor) of serine proteases of all the above-mentioned pathways. Recently, an autotranspo...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Dhillon, Arun, Deme, Justin C., Furlong, Emily, Roem, Dorina, Jongerius, Ilse, Johnson, Steven, Lea, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092270/
https://ncbi.nlm.nih.gov/pubmed/33758081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02823-20
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