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Original Antigenic Sin: How Original? How Sinful?

We review the phenomenon of “original antigenic sin” (OAS) in antibody responses to influenza A virus (IAV) infection or vaccination. OAS refers to the preferential induction of antibodies with higher affinity to priming versus boosting immunogens. We emphasize its mechanistic basis and origins in t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cold Spring Harb Perspect Med
Prif Awduron: Yewdell, Jonathan W., Santos, Jefferson J.S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091961/
https://ncbi.nlm.nih.gov/pubmed/31964645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a038786
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