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Original Antigenic Sin: How Original? How Sinful?
We review the phenomenon of “original antigenic sin” (OAS) in antibody responses to influenza A virus (IAV) infection or vaccination. OAS refers to the preferential induction of antibodies with higher affinity to priming versus boosting immunogens. We emphasize its mechanistic basis and origins in t...
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| Publié dans: | Cold Spring Harb Perspect Med |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8091961/ https://ncbi.nlm.nih.gov/pubmed/31964645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a038786 |
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