Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease

BACKGROUND: Identifying novel therapeutic targets is crucial for the successful development of drugs. However, the cost to experimentally identify therapeutic targets is huge and only approximately 400 genes are targets for FDA-approved drugs. As a result, it is inevitable to develop powerful comput...

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Bibliografske podrobnosti
izdano v:Alzheimers Res Ther
Main Authors: Tsuji, Shingo, Hase, Takeshi, Yachie-Kinoshita, Ayako, Nishino, Taiko, Ghosh, Samik, Kikuchi, Masataka, Shimokawa, Kazuro, Aburatani, Hiroyuki, Kitano, Hiroaki, Tanaka, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091739/
https://ncbi.nlm.nih.gov/pubmed/33941241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-021-00826-3
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