Mice With Targeted Deletion of ARC Kisspeptin Exhibit Immature Gametogenesis and Impaired Fertility

Hypothalamic kisspeptin is primarily synthesized in two discrete nuclei - the anteroventral periventricular (AVPV) and the arcuate (ARC) nuclei. We have previously developed a selective, conditional ARC kisspeptin knock-out (KO) mouse line, namely the Pdyn-Cre/Kiss(fl/fl) KO mice, that exhibited nor...

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Bibliographic Details
Published in:J Endocr Soc
Main Authors: Nandankar, Nimisha, Negron, Ariel L, Wolfe, Andrew M, Levine, Jon E, Radovick, Sally
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Neuroendocrinology and Pituitary
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090563/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.1107
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