Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing

The impact of the microenvironment on innate lymphoid cell (ILC)-mediated immunity in humans remains largely unknown. Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127(+) ILCs across four human tissues. Corre...

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Publicado no:Cell Res
Main Authors: Mazzurana, Luca, Czarnewski, Paulo, Jonsson, Viktor, Wigge, Leif, Ringnér, Markus, Williams, Teresa C., Ravindran, Avinash, Björklund, Åsa K., Säfholm, Jesper, Nilsson, Gunnar, Dahlén, Sven-Erik, Orre, Ann-Charlotte, Al-Ameri, Mamdoh, Höög, Charlotte, Hedin, Charlotte, Szczegielniak, Sylwester, Almer, Sven, Mjösberg, Jenny
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8089104/
https://ncbi.nlm.nih.gov/pubmed/33420427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-020-00445-x
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